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Etomidate analogues with improved pharmacokinetic and pharmacodynamic properties
专利权人:
THE GENERAL HOSPITAL CORPORATION
发明人:
Douglas E. Raines,Stuart A. Forman,Keith W. Miller,Syed Shaukat Husain,Joseph F. Cotten
申请号:
US14026456
公开号:
US09181197B2
申请日:
2013.09.13
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The invention is directed to compounds according to formula (I):where R1 is L1C(O)OT or L1C(O)OL2C(O)OT; R2 is a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, or R1; n is an integer from 0 to 5; each R3 is independently halogen or R2; L1 and L2 are each independently a bond, a substituted or unsubstituted C1-C10 alkylene, C2-C10 alkenylene, or C2-C10 alkynylene; and T is H, a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.
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