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ETOMIDATE ANALOGUES WITH IMPROVED PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES
专利权人:
The General Hospital Corporation
发明人:
Raines, Douglas,Forman, Stuart A.,Miller, Keith W.,Husain, Syed Shaukat,Cotten, Joseph F.
申请号:
AU2013242865
公开号:
AU2013242865B2
申请日:
2013.10.11
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
#$%^&*AU2013242865B220160526.pdf#####ABSTRACT The invention is directed to compounds according to formula (I): R3 - R2 N R1 N (I) where R1 is LiC(O)OT or LiC(O)OL 2C(O)OT; R2 is a substituted or unsubstituted C1-Cio alkyl, C2-Cio alkenyl, or C2-Cio alkynyl, or R1 ; n is an integer from 0 to 5; each R 3 is independently halogen or R2; Li and L 2 are each independently a bond, a substituted or unsubstituted C1-Cio alkylene, C2-Cio alkenylene, or C2-Cio alkynylene; and T is H, a substituted or unsubstituted C1-Cio alkyl, C2-Cio alkenyl, or C2-Cio alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.
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