STOCKLEY, Martin Lee,MACDONALD, Ellen Catherine,SHAH, Pritom,JORDAN, Allan,HITCHIN, James,HAMILTON, Niall
申请号：
ES16703836
公开号：
ES2778898T3
申请日:
2016.02.04
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
A compound, or a pharmaceutically acceptable salt or solvate thereof, having the structural Formula I shown below: ** (See formula) ** wherein: R1 and R2 are independently selected from H, (1-2C) alkyl, halo, cyano, nitro, hydroxyl, amino, mercapto, (1-2C) haloalkyl, (1-2C) alkoxy, (1-2C) fluoroalkoxy, A1 is N or C-Rd, where Rd is selected from H, halo , (1-2C) alkyl, cyano, nitro, hydroxyl, amino, (1-2C) haloalkyl, (1-2C) alkoxy, or (1-2C) haloalkoxy； A2 is N or C-Re, where Re is selected from H, F, Cl or (1-2C) alkyl； A3 is N or CRf, where Rf is selected from H, halo, (1-2C) alkyl, cyano, nitro, hydroxyl, amino, (1-2C) haloalkyl, (1-2C) alkoxy, (1-2C) haloalkoxy, NRgRh, ORg, C (O) Rg, C (O) ORg, OC (O) Rg, C (O) N (Rh) Rg, N (Rh) C (O) Rg, S (O) and Rg ( where y is 0, 1, or 2), SO2N (Rh) Rg, N (Rh) SO2Rg, or (CH2) zNRhRg (where z is 1, 2, or 3), where Rg and Rh are each independently selected from H or (1-2C) alkyl； L is a methylene optionally substituted by (1-2C) alkyl or oxo； Ar is a 5- or 6-membered heteroaryl optionally substituted by H, halo, (1-4C) alkyl, (1-4C) haloalkyl, OCF3, (1-4C) alkoxy, (2-4C) alkenyl, (2-4C ) alkynyl, (3-6C) cycloalkyl, (3-6C) cycloalkyl (1-2C) alkyl or a group of the Formula: ** (See formula) ** where: Ra and Ra 'are independently selected from H, fluoro, (1-2C) alkyl (1-2C) alkoxy or (1-2C) fluoroalkoxy； Rb and Rb 'are independently selected from H, fluoro, chloro, (1-2C) alkyl, (1-2Cfluoroalkoxy or (1-2C) alkoxy； Rc is selected from H, (1-4C) alkyl, halo, hydroxyl , (1-4C) haloalkyl, (1-4C) alkoxy, (1-4C) haloalkoxy, (2-4C) alkenyl, (2-4C) alkynyl, (3-6C) cycloalkyl, (3-6C) cycloalkyl ( 1-2C) alkyl, NRiRj, ORi, C (O) Ri, C (O) ORi, OC (O) Ri, C (O) N (Rj) Ri, N (Rj) C (O) Ri, S ( O) yRi (where y is 0, 1 or 2), SO2N (Rj) Ri, N (Rj) SO2Ri or (CH2) zNRjRi (where z is 1, 2 or 3), where Ri and Rj are each independently selected from H or (1-2C) alkyl； or Rc is a group of the Formula: -L1-B where: L1 is (1-2C) alkylene or -O- (1-2C) al
