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Pirido[3,2-d]pirimidinas trisustituidas, sus procedimientos de preparación y su uso en terapia
专利权人:
Centre National de la Recherche Scientifique (C.N.R.S.)
发明人:
ROUTIER, Sylvain,BENEDETTI, Hélène,BURON, Frédéric,HIEBEL, Marie-Aude,SAURAT, Thibault,GUILLAUMET, Gérald
申请号:
ES13750072
公开号:
ES2655284T3
申请日:
2013.08.16
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
It compound of general formula (I): ** (See formula) ** wherein: - R1 is selected from the group consisting of:. (Hetero) aryl comprising from 5 to 30 atoms, optionally substituted, and. NRaRb, Ra and Rb groups together form with the nitrogen atom to which they are attached, a heterocycle comprising from 5 to 30 atoms, optionally comprising an SO2 radical or another heteroatom selected from N, O, or S, said optionally substituted heterocycle - R2 is selected from the group consisting of:. halogen atoms selected from F, Br and I,. aryl containing from 5 to 30 carbon atoms, optionally substituted. -NRaRb groups, Ra and Rb which form together with the nitrogen atom to which they are attached, a heterocycle comprising from 5 to 30 atoms, optionally comprising an SO2 radical or another heteroatom selected from N , O, or S, he said heterocycle being optionally substituted and - R3 is selected from the group consisting of:. halogen atoms selected from F, Cl and I,. alkenyls comprising from 1 to 20 carbon atoms, optionally substituted. -C (O) Rc, Rc selecting group consisting of a hydrogen atom or an alkyl group comprising from 1 to 10 carbon atoms, said alkyl group being optionally substituted,. -C (O) ORc selecting Rc the group consisting of a hydrogen atom or an alkyl group comprising from 1 to 10 carbon atoms, said alkyl group being optionally substituted,. -C (Re)> = N- (ORd), selecting Rd and Re independently from the group consisting of a hydrogen atom or an alkyl group comprising from 1 to 10 carbon atoms. heterocycloalkyl comprising from 3 to 20 carbon atoms, optionally substituted. alkyls comprising 1 to 20 carbon atoms, optionally substituted by at least one substituent with the proviso that at least one of R1 and R2 represent respectively a group -NRaRb or -NRaRb group and their pharmaceutically acceptable salts, hydrates, diastereomers or enantiomers and the radicals "alkyl", " aryl "," heteroaryl "," alkenyl "," heterocycle "," heterocycloalkyl "and" cycloalky
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