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СПОСОБЫ ПОВЫШЕНИЯ ЖИЗНЕСПОСОБНОСТИ ИЛИ УВЕЛИЧЕНИЯ ПРОДОЛЖИТЕЛЬНОСТИ ЖИЗНИ ОРГАНА ИЛИ ЭКСПЛАНТА ОРГАНА
专利权人:
МОДЕРНА ТЕРАПЬЮТИКС; ИНК. (US)
发明人:
БАНСЕЛЬ Стефан (US),ДЕ ФУЖЕРОЛЛЬ Антонин (BE)
申请号:
RU2014129863
公开号:
RU2014129863A
申请日:
2012.12.21
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A method for improving the viability, function, or increased longevity explant organ or tissue or part thereof, comprising contacting said explant organ or tissue or part thereof with the composition comprising a modified mRNK.2. The method of claim. 1, characterized in that the body is selected from the group consisting of kidney, heart, lung, liver, pancreas, intestine, spleen, skin and glaza.3. The method of claim. 1, characterized in that the explant tissue is selected from the group consisting of heart valves, bone, vein, middle ear, cartilage, tendons and svyazok.4. A method according to claim. 2, characterized in that the composition based on the modified mRNA comprises mRNA, incorporated preparat.5. A method according to claim. 4, wherein the organ is a heart, or lung, and the drug is selected from the group consisting of saline, lipids, lipidoidov, polymer, liposome preparations, lipid nanoparticles, rapidly eliminated lipid nanoparticles formulations dynamic polikonyugatov, atupleksov , preparations dibutyltin maleate polymers PLGA, protamine based agents, penetrating peptides in cells, the conjugates of sugars or steroids, hydrogels, and sealants nositeley.6 cell systems. The method of claim. 5, characterized in that the contacting comprises administering the modified mRNA hozyain.7 organism. A method according to claim. 6, characterized in that the host organism is an organism donora.8. A method according to claim. 7, characterized in that the administration of a donor is carried out prior to any extraction procedure heart, lung or pancreas, or during recovery of the heart, lung or pancreatic zhelezy.9. A method according to claim. 8, characterized in that the donor organism1. Способ повышения жизнеспособности, функциональности или увеличения продолжительности жизни экспланта органа или ткани, или его части, включающий приведение в контакт указанного экспланта органа или ткани, или его части с составом, содержащим модифицированную мРНК.2. Способ по п.
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