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Condensed tricyclic compounds having aldose reductase inhibitory activity
专利权人:
国立大学法人富山大学
发明人:
豊岡 尚樹,加藤 敦,足立 伊佐雄
申请号:
JP2009546274
公开号:
JP5366211B2
申请日:
2008.12.17
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
A fused tricyclic compound having aldose reductase inhibitory activity and shown by the following formula, wherein R 1 independently represents 1 to 3 atoms or substituents selected from a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl, cycloalkyl, alkylene, or alkoxy group, and a protected or unprotected hydroxyl or carboxyl group, R 2 represents a protected or unprotected carboxyl group, R 3 independently represents 1 or 2 atoms or substituents selected from a hydrogen atom, a halogen atom, an oxo group, a substituted or unsubstituted alkyl or alkoxy group, and a protected or unprotected carboxyl group, A represents an alkylene group, and B represents an oxygen atom, a sulfur atom, or a group shown by the following formula, wherein R 4 represents an alkyl or aryl group substituted with an aryl, cycloalkyl, or heterocyclic group, and X represents an oxygen atom or a sulfur atom.
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