BRODNEY, Michael Aaron (US),БРОДНИ, Майкл Аарон (US),BUTLER, Christopher Ryan (US),БАТЛЕР, Кристофер Райан (US),MCALLISTER, Laura Ann (US),МАКАЛЛИСТЕР, Лора Энн (US),HELAL, Christopher John (US),ХЕЛАЛ
申请号：
RU2019122800
公开号：
RU0002720203C1
申请日:
2018.01.08
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula IIor pharmaceutically acceptable salts thereof, where R1 is H； fragment M-1 of formula IM-1 is a fragment of formula M-1a, M-1b or M-1c:, , ,each of R2A and R2C independently represents -NR3S(=O)2R4, -NR3C(=O)R4； R5 or -OR5； R2B is selected from a group comprising [4-(trifluoromethyl)-1H-pyrazol-1-yl]methyl,cyclopentylcarbonyl)(methyl)amino-(tert-butylsulfonyl)(methyl)amino-(2,2-dimethylpropanoyl)(methyl)amino-, 4-(trifluoromethyl)-1H-pyrazol-1-yl-, 4-fluoro-1H-pyrazol-1-yl-, 3-cyanophenyl-, 6-(trifluoromethyl)pyridin-2-yl-, 5-fluoropyridin-2-yl-, 4-(difluoromethyl)-1H-pyrazol-1-yl-, 4-tert-butyl-1H-pyrazol-1-yl-, 4-chloro-1H-pyrazol-1-yl-, 4-cyclopropyl-1H-pyrazol-1-yl-, 4-methyl-1H-pyrazol-1-yl-, 2-fluorophenyl-, 4-cyano-3-fluorophenyl-, 3-cyano-4-fluorophenyl-, 5-cyano-2-fluorophenyl-, 4-cyanophenyl-, 2,6-difluorophenyl-, 2,4-difluorophenyl-, 4-fluorophenyl-, 4-(difluoromethyl)pyridin-2-yl-, 6- (difluoromethyl)pyridin-3-yl-, 5-cyanopyridin-2-yl-, 5-(difluoromethyl)pyridin-2-yl-, 5-(trifluoromethyl)pyridin-2-yl-, pyridin-2-yl-, 3-tert-butyl-1H-pyrazol-1-yl-, 3-(trifluoromethyl)-1H-pyrazol-1-yl-, 3,4-dimethyl-1H-pyrazol-1-yl-,{[(3,3-difluorocyclobutyl)methyl]sulfonyl}(methyl)amino-, [(3,3-difluorocyclobutyl)carbonyl](methyl)amino-, 1H-indazol-1-yl-, 3-cyano-2-fluorophenyl-, and 4-cyano-2-fluorophenyl-； each R3 independently represents C1-3 alkyl； each R4 is independently selected from C1-6 alkyl, C3-7 cycloalkyl, (C3-7 cycloalkyl)-C1-2 alkyl-, (phenyl)-C1-2 alkyl- and phenyl, where each of the selected versions is substituted with 0, 1, 2 or 3 halogens； and each R5 is phenyl or 5- or 6-member heteroaryl, wherein each phenyl or 5- or 6-member heteroaryl is substituted with 0, 1, 2 or 3 substitutes (see claim 1)； methods of producing； a composition containing such compounds and use thereof for treating MAGL mediated diseases and disorders.EFFECT: compounds of the present invention can be used for
