Myostatin binding agents, nucleic acids encoding the same, and methods of treatment

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专利权人:

Amgen Inc.

发明人:

Huiquan Han,Hosung Min,Thomas Charles Boone

申请号：

US13682580

公开号：

US08920798B2

申请日:

2012.11.20

申请国别(地区):

US

年份:

2014

代理人:

摘要：

The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such as a polymer or an Fc domain. The binding agents of the present invention produced increased lean muscle mass when administered to animals and decreased fat to muscle ratios. Therapeutic compositions containing the binding agents of the present invention are useful for treating muscle-wasting disorders and metabolic disorders including diabetes and obesity.

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