HILL, Oliver,GIEFFERS, Christian,THIEMANN, Meinolf,BUCHANAN, Fritz G.,PHILLIPS, Darren C.,LAPPE, Susan E.
申请号:
AU2018271369
公开号:
AU2018271369A1
申请日:
2018.11.30
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
#$%^&*AU2018271369A120181220.pdf#####SINGLE-CHAIN TRAIL-RECEPTOR AGONIST PROTEINS ABSTRACT Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.