PARK, John, E.,DORNER-CIOSSEK, Cornelia,HOERER, Stefan,KUSSMAUL, Lothar,LENTER, Martin,ZIMMERMANN, Katharina,BESTE, Gerald,LAEREMANS, Toon,MERCHIERS, Pascal,VERCAMMEN, Jo
申请号:
TN2012000434
公开号:
TN2012000434A1
申请日:
2012.08.31
申请国别(地区):
TN
年份:
2014
代理人:
摘要:
The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.