THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
Jie Liu,Irving L. Weissman,Ravindra Majeti
申请号：
US14656431
公开号：
US09382320B2
申请日:
2015.03.12
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Humanized or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to and neutralize human CD47, and find use in various therapeutic methods. Preferred are non-activating antibodies. Embodiments of the invention include isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the humanized or chimeric anti-CD47 monoclonal antibodies； and cell lines that produce these monoclonal antibodies. Also provided are amino acid sequences of the antibodies.
