The Board of Trustees of the Leland Stanford Junior University
发明人:
LIU, Jie,WEISSMAN, Irving L.,MAJETI, Ravindra
申请号：
AU2020203132
公开号：
AU2020203132A1
申请日:
2020.05.13
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2020203132A120200604.pdf#####ABSTRACT OF THE INVENTION [00109] Humanized or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to and neutralize human CD47, and find use in various therapeutic methods. Preferred are non-activating antibodies. Embodiments of the invention include isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the humanized or chimeric anti-CD47 monoclonal antibodies； and cell lines that produce these monoclonal antibodies. Also provided are amino acid sequences of the antibodies.
