PROBLEM TO BE SOLVED: To provide pharmaceutical compositions for treating, preventing or alleviating conditions and inflammation associated with inflammatory diseases and conditions.SOLUTION: Disclosed is a pharmaceutical composition comprising: a. a therapeutic amount of topically active corticosteroid； b. an antioxidant； c. a buffer； d. a surfactant； e. a preservative, a flavoring agent, a sweetener, or a combination thereof； f. at least one additional excipient for increasing the interaction of a surface of the esophagus with the composition； g. 0-500 mg/ml of dextrose； and h. an aqueous liquid vehicle, where the composition is physically or chemically stable and suitable for single or multiple dose administration with a unit dose of 1-20 ml, and has at least a viscosity of 35 cP with a shear rate of 13.2 sec.SELECTED DRAWING: Figure 1【課題】炎症性疾患及び炎症状態に付随する症状及び炎症を治療、予防又は軽減する医薬組成物の提供。【解決手段】ａ．治療有効量の局所活性コルチコステロイド、ｂ．酸化防止剤、ｃ．緩衝剤、ｄ．界面活性剤、ｅ．防腐剤、着香剤、甘味料、又はこれらの組み合わせ、ｆ．食道表面と当該医薬組成物との相互作用を高める少なくとも１つの追加賦形剤、ｇ．０～５００ｍｇ／ｍLのデキストロース、及び、ｈ．水性液状ビヒクルを含有し、物理的又は化学的に安定し、単回投与又は反復投与に適しており、単位用量が１ｍＬ～２０ｍＬであり、１３．２sec-1の剪断速度で少なくとも３５ｃＰの粘度をもつことを特徴とする、医薬組成物。【選択図】図１
