PROBLEM TO BE SOLVED: To provide pharmaceutical compositions for treating, preventing or alleviating conditions and inflammation associated with inflammatory diseases and conditions.SOLUTION: Disclosed is a pharmaceutical composition comprising: a. a therapeutic amount of topically active corticosteroid; b. an antioxidant; c. a buffer; d. a surfactant; e. a preservative, a flavoring agent, a sweetener, or a combination thereof; f. at least one additional excipient for increasing the interaction of a surface of the esophagus with the composition; g. 0-500 mg/ml of dextrose; and h. an aqueous liquid vehicle, where the composition is physically or chemically stable and suitable for single or multiple dose administration with a unit dose of 1-20 ml, and has at least a viscosity of 35 cP with a shear rate of 13.2 sec.SELECTED DRAWING: Figure 1【課題】炎症性疾患及び炎症状態に付随する症状及び炎症を治療、予防又は軽減する医薬組成物の提供。【解決手段】a.治療有効量の局所活性コルチコステロイド、b.酸化防止剤、c.緩衝剤、d.界面活性剤、e.防腐剤、着香剤、甘味料、又はこれらの組み合わせ、f.食道表面と当該医薬組成物との相互作用を高める少なくとも1つの追加賦形剤、g.0~500mg/mLのデキストロース、及び、h.水性液状ビヒクルを含有し、物理的又は化学的に安定し、単回投与又は反復投与に適しており、単位用量が1mL~20mLであり、13.2sec-1の剪断速度で少なくとも35cPの粘度をもつことを特徴とする、医薬組成物。【選択図】図1