VAN RIJN, RACHEL DEBORAH,LOOZEN, HUBERT,TIMMERS, CORNELIS,VAN DER VEEN, LARS,KARSTENS, WILLEM
申请号：
ES09708584
公开号：
ES2373022T3
申请日:
2009.02.06
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound according to the general formula I Formula I or a pharmaceutically acceptable salt thereof, wherein the C5-C6 bond may be saturated or unsaturated, R1 is halogen, cyano, (C1-6) alkyl, (C2-) alkenyl 6), (C2-6) alkynyl, (C3-6) cycloalkyl, (C5-6) cycloalkenyl, or phenyl or heteroaryl (C1-5), each of said phenyl and heteroaryl moieties being optionally independently substituted with one or more substituents selected from R13； R2 is H, cyano, halogen, (C1-4) alkyl, (C1-4) alkoxy-(C1-4) alkyl, hydroxy (C1-4) alkyl, formyl, (C1-4) alkylcarbonyl or C = N-OH , C = N-OCH3； R3 is R15, R16-amino or R3 is (C1-6) alkyl, (C3-6) cycloalkyl, (di) [(C1-4) alkyl] (C1-4) aminoalkyl, or R3 is heterocycloalkyl (C2-6) ) -C 1-4 alkyl, the heterocycloalkyl (C 2-6) moiety of which may be optionally substituted with (C 1-4) alkylcarbonyl or C 3-6 cycloalkylcarbonyl, or R 3 is a group selected from R 7 is H, halogen or methyl； R8 is H, halogen, (C1-4) alkyl, (C1-4) alkoxy, (C1-4) alkoxy-5 (C1-4) alkyl or hydroxy； R9 is H, formyl, halogen, hydroxy, amino, cyano, nitro, alkynyl (C2-6), cycloalkoxy (C3-6), heterocycloalkoxy (C2-5), heteroaryloxy (C2-5), (di) [alkyl ( C1-4)] aminocarboxy, (C1-6) alkylcarbonyl, (C1-4) alkoxycarbonyl, (di) [(C1-4) alkyl] aminocarbonyl, heterocycloalkylcarbonyl (C2-6), (di) [C1-4 alkyl )] amino, heterocycloalkylcarbonyl (C2-6) amino, (di) [alkyl (C1-4)] aminocarbonylamino, alkoxycarbonyl (C1-4) amino, (di) [alkyl (C1-4)] aminosulfonylamino, alkylsulfonyl (C1- 4) amino, 1-imidazolidinyl-2-one, 3-oxazolidinyl-2-one, 1-pyrrolidinyl-2-one, or R9 is (C1-6) alkyl, (C1-6) alkoxy, (C2-6) alkenyl ), (C 1-6) alkylcarbonyl or C2-6 heterocycloalkyl, C2-5 heteroarylaminocarbonyl, each of said alkyl, alkoxy, alkenyl, heterocycloalkyl and heteroaryl being optionally substituted independently with one or more substituents selected from R14, or R9 is heteroaryl (C1-5), phenyl or phenoxy, all optionally independently substituted with u no or more substituents selected from
