KIM, CHANG JU,김창주,LEE, SI BEUM,이시범,KIM, JONG MIN,김종민,JEONG, SUNG EUN,정성은
申请号：
KR1020120010508
公开号：
KR1020130089112A
申请日:
2012.02.01
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A fast dissolving oral film containing sildenafil citrate salt is provided to improve bitter taste by mixing water soluble polymer, appropriate plasticizer, and sweetener, and to have a rapid effect by fast dissolving in the oral cavity.CONSTITUTION: A fast dissolving oral film comprises sildenafil citrate salt, water soluble polymers, and a plasticizer. The water soluble polymers are more than one kind of groups selected from among hydroxypropylmethylcellulose (HPMC), gelatin, carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), pectin, polyvinyl pyrrolidone (PVP), hydroxypropyl cellulose (HPC), and polyethylene oxide (PEO). A manufacturing method of the fast dissolving oral film comprises: a first step of dissolving the sildenafil citrate salt, water soluble polymers, and the plasticizer in solvent a second step of forming the solution as film-type a third step of drying the film and a fourth step of binding the dried film to two layers.COPYRIGHT KIPO 2013[Reference numerals] (AA) Example 1 (BB) Example 4 (CC) Example 7 (DD) Example 2 (EE) Example 5 (FF) Example 8 (GG) Example 3 (HH) Example 6 (II) Example 9본 발명은 실데나필 시트레이트염을 포함하는 속효성 구강 필름 및 이의 제조방법에 관한 것으로, 더욱 상세하게는 수용성 고분자와 적절한 가소제 및 감미제의 배합을 통해 쓴맛을 개선시키면서 동시에 구강 내에서의 빠른 용해를 통해 신속히 효과를 발휘할 수 있는 실데나필 시트레이트염을 포함하는 속효성 구강 필름 및 이의 제조방법에 관한 것이다.
