PROBLEM TO BE SOLVED: To provide a composition for inhibiting differentiation that inhibits differentiation of osteoclast precursor cells to osteoclasts and comprises D-allose as an active ingredient.SOLUTION: The composition for inhibiting differentiation to osteoclast inhibits differentiation of osteoclast precursor cells to osteoclasts by promoting expression of thioredoxin-interacting protein (TXNIP) or inhibiting expression of thioredoxin and contains D-allose as an active ingredient.COPYRIGHT: (C)2012,JPO&INPIT【課題】破骨細胞前駆細胞の破骨細胞への分化を抑制するD-アロースを有効成分とする分化抑制組成物の提供。【解決手段】チオレドキシン結合蛋白質(TXNIP) の発現を促進またはチオレドキシン(Thioredoxin)の発現を抑制させて破骨細胞前駆細胞の破骨細胞への分化を抑制するD-アロースを有効成分とする破骨細胞への分化抑制組成物【選択図】図10