GREYSTONE MEDICAL GROUP, INC.;MONROE, STEPHEN, H.;HOEKSTRA, HANS;VAN DEN BERG, A., J., J.
发明人:
MONROE, STEPHEN, H.,HOEKSTRA, HANS,VAN DEN BERG, A., J., J.
申请号：
WO2003US41038
公开号：
WO2004057965(A1)
申请日:
2003.12.23
申请国别(地区):
世界知识产权组织国际局
年份:
2004
代理人:
摘要：
Reactive oxygen species associated with a wound are modulated through treatment of the wound with a solution of metal ions selected from the group consisting of potassium ions, zinc ions, calcium ions and rubidium ions, at a pH of between about 5 and about 7. Preferably, citric acid is employed to adjust the pH. Application of the extract to a wound exhibiting superoxide anions has been found to be effective in the treatment of these wounds through the reduction of the level of superoxide anions. Moreover, treatment of partial thickness excision wounds as well as contact burn wounds with the present composition has been found to improve epithelialization of these wounds. In addition to the antioxidant activity of the present invention, treatment of the wound employing the present composition produces inhibitory effects on ROS production by human PMNs and on human complement activation, and therefore, is further beneficial in chronic wound management.
