Referring to an amide Derivative of formula (i), where X is n or C (R5) and F, CL, BR, I, among others r1 is alkyl haloalquilo C1 - C6 C1 - C6, among others R2 is H, F, C1 - C6 alkyl, between other R5 is H, F, CL, among others.Preferred compounds are: N - [2,4-difluoro-3 - (4 - methyl - 7h pyrrolo [2,3-d] pyrimidine 5 - carbonyl) - phenyl] - 3 - trifluoromethyl - benzenesulfonamide propane sulfonic acid) - 1 - [3 - (4 - ethoxy - 7h pyrrolo [2,3-d] pyrimidine 5 - carbonyl) - 2.4 - difluoro - amide phenyl] -, N - [2,4-difluoro-3 - (4 - methoxy - 7h pyrrolo [2,3-d] pyrimidine 5 - ca Rbonil) phenyl] - 4 - propyl - benzenesulfonamide, among others.It also relates to a Pharmaceutical composition. One or more such compounds inhibit the Protein Kinase RAF and are useful in the treatment of melanoma, glioma, Lung Cancer, ovarian cancer, among othersREFERIDA A UN DERIVADO DE AMIDA DE FORMULA (I), DONDE X ES N O C(R5) Y ES F, Cl, Br, CN, OH, ENTRE OTROS R1 ES ALQUILO C1-C6, HALOALQUILO C1-C6, ENTRE OTROS R2 ES H, F, ALQUILO C1-C6, ENTRE OTROS R5 ES H, F, Cl, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[2,4-DIFLUORO-3-(4-METIL-7H-PIRROLO[2,3-d]PIRIMIDIN-5-CARBONIL)-FENIL]-4-TRIFLUOROMETIL-BENCENOSULFONAMIDA, ACIDO PROPANO-1-SULFONICO[3-(4-ETOXI-7H-PIRROLO[2,3-d]PIRIMIDIN-5-CARBONIL)-2,4-DIFLUORO-FENIL]-AMIDA, N-[2,4-DIFLUORO-3-(4-METOXI-7H-PIRROLO[2,3-d]PIRIMIDIN-5-CARBONIL)-FENIL]-4-PROPIL-BENCENOSULFONAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LAS UNA O MAS PROTEINAS CINASAS RAF Y SON UTILES EN EL TRATAMIENTO DE MELANOMA, GLIOMA, CANCER PULMONAR, CANCER OVARICO, ENTRE OTROS
