Referring to a pirrolopiridina derivative Compound of formula (i), wherein R1 is pyridine, Benzyl, fluorobencilo, among others R2 is H or F R3 is H, CL, methoxy or CN R4 is H, Methyl, CL, CN, among others.Preferred compounds are: N - [3 - (5 - Chloro - 1H pyrrolo [2,3-b] pyridine - 2 - carbonyl) - phenyl] - difluoro - 2.4 - 2.5 - difluoro - benzenesulfonamide, N - [3 - (5 - Chloro - 1H pyrrolo [2,3-b] pyridine - 2 - carbonyl) - phenyl] - Difluoro - 2.4 - 2.6 - difluoro - benzenesulfonamide, N - [2,4-difluoro-3 - (5 - methoxy - 1H pyrrolo [2,3-b] pyridine - 2 - Coal IL) phenyl] - 2 - fluoro - benzenesulfonamide, among others.These compounds inhibit one or more Protein Kinases including, RAF, RAF, b-raf and c-raf and are useful in the treatment of melanoma, glioma, colorectal cancer, Lung Cancer, among othersREFERIDA A UN COMPUESTO DERIVADO DE PIRROLOPIRIDINA DE FORMULA (I), DONDE R1 ES PIRIDINA, BENCILO, FLUOROBENCILO, ENTRE OTROS R2 ES H O F R3 ES H, Cl, METOXI O CN R4 ES H, Cl, METILO, CN, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[3-(5-CLORO-1H-PIRROLO[2,3-b]PIRIDINA-3-CARBONIL)-2,4-DIFLUORO-FENIL]-2,5-DIFLUORO-BENCENOSULFONAMIDA, N-[3-(5-CLORO-1H-PIRROLO[2,3-b]PIRIDINA-3-CARBONIL)-2,4-DIFLUORO-FENIL]-2,6-DIFLUORO-BENCENOSULFONAMIDA, N-[2,4-DIFLUORO-3-(5-METOXI-1H-PIRROLO[2,3-b]PIRIDINA-3-CARBONIL)-FENIL]-2-FLUORO-BENCENOSULFONAMIDA, ENTRE OTROS. DICHOS COMPUESTOS INHIBEN UNA O MAS PROTEINA QUINASAS RAF, INCLUYENDO, A-RAF, B-RAF Y C-RAF Y SON UTILES EN EL TRATAMIENTO DE MELANOMA, GLIOMA, CANCER COLORRECTAL, CANCER DE PULMON, ENTRE OTROS
