SMITH, STEPHON CORNELL,LI, RENHUA,MITCH, CHARLES HOWARD,VETMAN, TATIANA NATALI
申请号：
PE0012152013
公开号：
PE09972014A1
申请日:
2011.11.15
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Relates to compounds of formula (i) wherein: R1 and R2 are independently H alcoxicarboniloximetilo alquilcarboniloximetilo C1, C3, C1 - C5 or C3 C6 cicloalquilcarboniloximetilo R3 is Methyl, Fluorine or Chlorine R4 is hydroxyl, amino, metilcarbonilamino, 1,2,4 - triazoliltio n is 1 or 2.Preferred compounds are: acid (1S, 2R, 3S, 4S, 5R, 6R) - 2-amino-3 - (3,4-difluorophenyl) {[]} - 4 - Methyl sulfanyl hidroxibiciclo [3.1.0] hexan - 2.6 - dicarboxilico bis ({[(1 - metiletoxi) carbonyl] oxy] methyl) (1S, 2R, 3S, 4S, 5R, 6R) - 2-amino-3 - (3,4-difluorophenyl) {[]} - 4 - Methyl sulfanyl hidroxibiciclo [3.1.0] hexan - 2.6 - dicarboxilat Or, among others. Also referred to a Pharmaceutical compositionSE REFIERE A COMPUESTOS DE FORMULA (I) DONDE: R1 Y R2 SON INDEPENDIENTEMENTE H, ALCOXICARBONILOXIMETILO C1-C3, ALQUILCARBONILOXIMETILO C1-C5, O CICLOALQUILCARBONILOXIMETILO C3-C6 R3 ES METILO, FLUORO O CLORO R4 ES HIDROXILO, AMINO, METILCARBONILAMINO, 1,2,4-TRIAZOLILTIO n ES 1 O 2. SON COMPUESTOS PREFERIDOS: ACIDO (1S,2R,3S,4S,5R,6R)-2-AMINO-3-{[(3,4-DIFLUOROFENIL)SULFANIL]METIL}-4-HIDROXIBICICLO[3.1.0]HEXAN-2,6-DICARBOXILICO BIS({[(1-METILETOXI)CARBONIL]OXI}METIL)(1S,2R,3S,4S,5R,6R)-2-AMINO-3-{[(3,4-DIFLUOROFENIL)SULFANIL]METIL}-4-HIDROXIBICICLO[3.1.0]HEXAN-2,6-DICARBOXILATO ENTRE OTROS. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA
