Pyrrolobenzodiazepines and targeted conjugates

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专利权人:

SEATTLE GENETICS, INC.;MEDIMMUNE LIMITED

发明人:

Scott Jeffrey,Patrick Burke,Philip Wilson Howard

申请号：

US15182649

公开号：

US09707301B2

申请日:

2016.06.15

申请国别(地区):

US

年份:

2017

代理人:

摘要：

This invention relates to pyrrolobenzodiazepines (PBDs), in particular pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position in each monomer unit, and their inclusion in targeted conjugates. The differing substituent groups may offer advantages in the preparation and use of the compounds, particularly in their biological properties and the synthesis of conjugates, and the biological properties of these conjugates.

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