ROZEMA Devid B.,LYUIS Devid L.,VEJKFILD Darren KH.,KITAS Erik A.,KHADVIGER Filipp,VOLF Dzhon A.,ROEL Ingo,MOR Piter,KHOFMANN Torsten,ZHAN-KHOFFMAN Kerstin,MYULLER Khans Martin,OTT Gyunter,BLOKHIN Andrej V.,KARLSON Dzheffri S.,BENSON Dzhonatan D.
申请号：
RU20130117286
公开号：
RU2619453(C2)
申请日:
2011.12.28
申请国别(地区):
俄罗斯
年份:
2017
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to compounds for the reversible modification of an amphipathic membrane-active polyamine and a polymer to deliver polynucleotide into cells in vivo. Amphipathic membrane-active polyamines are reversibly modified by dipeptide amidobenzylcarbonate masking agents which are enzymatically chipping. Reversibly modified polyamines (dynamic polyconjugates or combined surface disinfectant KDP) are also covalently bound to a polynucleotide of RNAi or introduced with RNAi polynucleotide targeted conjugate molecules.EFFECT: invention provides masking of membrane activity of polymer, and reversibility provides sensitivity to physiological conditions.17 cl, 15 tbl, 4 dwg, 16 ex
