Steven Charles Defina;Neel Kumar Anand;Charles M. Blazey;Joerg Bussenius;Angie I. Kim;Owen Joseph Bowles;Abigail R. Kennedy;Jeffry Kimo Curtis;Jean-Claire L. Manalo;Simona Costanzo;Larisa Dubenko;Csab
发明人:
Neel Kumar Anand,Charles M. Blazey,Owen Joseph Bowles,Joerg Bussenius,Simona Costanzo,Jeffry Kimo Curtis,Larisa Dubenko,Abigail R. Kennedy,Steven Charles Defina,Angie I. Kim,Jean-Claire L. Manalo,Csab
申请号：
US12903031
公开号：
US08697737B2
申请日:
2010.10.12
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to compounds of the Formula I, wherein G, A, X1, X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.
