Dubenko, Larisa,Tsang, Tsze H.,Le, Donna Tra,Canne Bannen, Lynne,Defina, Steven Charles,Huang, Ping,Costanzo, Simona,Xu, Wei,Bussenius, Joerg,Mac, Morrison B.,Anand, Neel K.,Franzini, Maurizio,Nuss, J
申请号：
AU2005249380
公开号：
AU2005249380C1
申请日:
2005.04.22
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention relates to compounds of the Formula (I) and (II) wherein R, R, R-R, m, n, X-X, and Q are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.
