Bussenius, Joerg,Defina, Steven Charles,Kennedy, Abigail R.,Bowles, Owen Joseph,Kim, Angie I.,Rice, Kenneth D.,Dubenko, Larisa,Blazey, Charles M.,Curtis, Jeffry Kimo,Manalo, Jean-Claire L.,Tsang, Tsze
申请号：
AU2005244736
公开号：
AU2005244736B2
申请日:
2005.03.25
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention relates to compounds of the Formula I, wherein G, A, X1,X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinaseenzymatic activity to modulate cellular activities such as proliferation,differentiation, programmed cell death, migration and chemoinvasion. Compoundsof the invention inhibit, regulate and/or modulate kinases, particularly Raf.Methods of using and preparing the compounds, and pharmaceutical compositionsthereof, to treat kinase-dependent diseases and conditions are also an aspectof the invention.
