Henryk Borowy-Borowski,Marianna Sikorska-Walker,P. Roy Walker
申请号：
US12431610
公开号：
US08524696B2
申请日:
2009.04.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula:{X—OOC—[(CH2)n—COO]m}p—Y (I)wherein:X is a residue of a hydrophobic moiety,Y is a residue of a hydrophilic moiety,p is 1 or 2,m is 0 or 1, andn is an integer greater than or equal to 0are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is α-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.
