Anthony Conway,Sumiti Jain,Gary K. Lee,David Paschon,Edward J. Rebar,Lei Zhang
申请号：
US16009975
公开号：
US20180362926A1
申请日:
2018.06.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed herein are methods and compositions for inactivating TCR and/or HLA genes, using engineered nucleases comprising at least one DNA binding domain and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding nucleases, vectors comprising polynucleotides encoding nucleases and cells comprising polynucleotides encoding nucleases and/or cells comprising nucleases are also provided.
