Patrick De Baetselier,Geert Raes,Steve Schoonooghe,Jens De Vos,Tony Lahoutte,Nick Devoogdt,Sophie Hernot,Gezim Bala,Simon Tierens
申请号:
US14775510
公开号:
US20160024213A1
申请日:
2014.03.17
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The disclosure relates to the field of cardiovascular diseases. In particular, immunoglobulin single variable domains directed against macrophage mannose receptor (MMR) are provided that can be used in the diagnosis, prognosis and/or monitoring of cardiovascular diseases or as therapeutics. Also, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are useful at different stages of cardiovascular diseases, including post-infarction cardiovascular events. Further, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are particularly useful for the in vivo targeting and/or imaging of vulnerable atherosclerotic plaques.