De Baetselier, Patrick,Raes, Geert,Schoonooghe, Steve,De Vos, Jens,Lahoutte, Tony,Devoogdt, Nick,Hernot, Sophie,Bala, Gezim,Tierens, Simon
申请号：
AU2014229952
公开号：
AU2014229952B2
申请日:
2014.03.17
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present invention relates to the field of cardiovascular diseases. In particular, immunoglobulin single variable domains directed against macrophage mannose receptor (MMR)are provided that can be used in the diagnosis, prognosis and/or monitoring of cardiovascular diseases or as therapeutics. Also, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the invention are useful at different stages of cardiovascular diseases, including post-infarction cardiovascular events. Further, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the invention are particularly useful for the in vivo targeting and/or imaging of vulnerable atherosclerotic plaques.
