Local, concomitant administration of tolerogenic synthetic nanocarriers to reduce type I and type IV hypersensitivity

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专利权人:

Selecta Biosciences; Inc

发明人:

Maldonado, Roberto A.

申请号：

AU2019250117

公开号：

AU2019250117A1

申请日:

2019.10.15

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

#$%^&*AU2019250117A120191107.pdf#####Abstract The present application is directed to methods for reducing Type I and Type IV hypersensitivity in a patient who is at risk of a local inflammatory reaction when administered therapeutic macromolecules. The methods comprise providing a therapeutic dose of a therapeutic macromolecule which is not attached to synthetic nanocarriers, providing a composition comprising synthetic nanocarriers attached to immunosuppressants, and locally administering the composition and the therapeutic macromolecule concomitantly.

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