The present invention relates to low concentration synergistic Xenon-Argon gas mixtures argon for use in a method for preventing and/or treating ischemic insults, wherein- the volume proportion of xenon is between 5 and 20 %,- the volume proportion of argon is between 5 and 20 %, and- the pharmaceutical composition further comprises a gas complement to reach 100 % volume proportion,- the method includes comprises restoration of blood flow and the gas mixture is administered to the patient before, during, or after blood flow restoration.