Frederik Jan Rita Rombouts,Andrés Avelino Trabanco-Suarez,Henricus Jacobus Maria Gijsen,Gregor James MacDonald,François Paul Bischoff,Sergio-Alvar Alonso-de-Diego,Adriana Ingrid Velter,Yves Emiel Mari
申请号：
US14400663
公开号：
US09181245B2
申请日:
2013.05.16
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention is concerned with novel substituted 3,4-dihydro-2H-pyrido[1,2- a]pyrazine-1,6-dione derivatives of Formula (I) wherein R1, R2, R3, R4, R5, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
