François Paul Bischoff,Adriana Ingrid Velter,Frederik Jan Rita Rombouts,Michel Anna Jozef De Cleyn,Sven Franciscus Anna Van Brandt,Henricus Jacobus Maria Gijsen,Chiara Zavattaro,Frans Alfons Maria Van
申请号：
US16038761
公开号：
US10562897B2
申请日:
2018.07.18
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I)wherein R1, R2, R3, R4, R5, L, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
