BISCHOFF, FRANCOIS PAUL,GIJSEN, HENRICUS JACOBUS MARIA,VAN DEN KEYBUS, FRANS ALFONS MARIA,ROMBOUTS, FREDERIK JAN RITA
申请号：
CA2889249
公开号：
CA2889249A1
申请日:
2013.12.19
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention is concerned with novel tricyclic 3,4-dihydro-2H-pyrido[l,2-a]pyrazine-l,6-dione derivatives of Formula (I) wherein R1, R2, R3, R4, L, Y, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament for the treatment of i.a. Alzheimer's disease.
