KUO, GEE-HONG,郭纪鸿,郭紀鴻,ZHANG, YAN,项言,項言,SHEN, LAN,沈兰,沈蘭,LU, SONGFENG,卢松风,盧松風,DEMAREST, KEITH T.,德玛斯,德瑪斯,PELTON, PATRICIA,皮尔顿,皮爾頓
申请号：
TW096113405
公开号：
TWI404712B
申请日:
2007.04.17
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The invention is directed to compounds of Foumula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndrome, hypertension, ischemia, stroke, irritable bowel disorder, inflammation, cataract, cardiovascular diseases, Metabolic X syndrome, hyper-LDL-cholesterolemia, dyslipidemia (including hypertriglyceridemia, hypercholesterolemia, mixed hyperlipidemia, and hypo-HDL-cholesterolemia), atherosclerosis, obesity, and other disorders related to lipid metabolism and energy homeostasis complications thereof, using compounds of the invention are also described.本發明係關於作為PPAR作用劑使用的式(I)化合物。同時也揭示使用本發明之化合物治療一或多種病情，包括但不限於糖尿病、腎病變、神經病變、視網膜病變、多囊性卵巢徵候群、高血壓、缺血、中風、應激性腸疾、發炎、白內障、心血管病、代謝性X徵候群、高－LDL－膽固醇症、脂肪代謝障礙症(包括高三酸甘油酯症、高膽固醇症、混合性高脂血症及低－HDL－膽固醇症)、動脈粥樣硬化症、肥胖症、及與脂質代謝相關的其他疾病及其能量恆定併發症。
