Compounds having the structure or their salts: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia, male baldness, muscle atrophy and weakness, sarcopenia, male hypogonadism, erectile dysfunction, female sexual dysfunction and osteoporosis. They can be formulated together with pharmaceutically acceptable diluent or carrier or otherwise made into any pharmaceutical dosage form. Combinations with other active pharmaceutical agents are also disclosed.係提供一種具下列結構之化合物或其鹽類：係用於治療或降低雄激素-依賴性疾病，如前列腺癌、良性前列腺增生、多囊性卵巢症候群、痤瘡、多毛症、脂溢性皮炎、雄激素性脫髮、雄性禿、肌肉萎縮和無力、肌少症、男性性腺功能減退症、勃起功能障礙、女性性功能障礙及骨質疏鬆。其可與醫藥上可接受之稀釋劑或載體一同配製，或製造為任何醫藥藥劑形式。亦揭示具有其他活性醫藥試劑之組合物。
