Kreppner, Wayne,Fogarty, Siobban,Oberegger, Werner,Maes, Paul José Pierre Marie
申请号：
AU2017204182
公开号：
AU2017204182A1
申请日:
2017.06.20
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
#$%^&*AU2017204182A120170720.pdf#####An intranasal testosterone gel for topical administration into a nasal cavity to control release of testosterone over a period of at least about 6 hours following the nasal cavity administration to provide replacement or supplemental testosterone in a male or female for treating male or female testosterone deficiency, without causing an unacceptable spike in testosterone blood level over dose life, said intranasal testosterone gel comprising: (a) testosterone in an amount effective to treat male/female testosterone deficiency； (b) at least one lipophilic or partly lipophilic carrier； (c) a super solvent for increasing testosterone solubility in said intranasal testosterone gel； and (d) a viscosity regulating agent in an amount effective to control the release of said testosterone from said intranasal testosterone gel, wherein said intranasal testosterone gel does not need a surfactant. An applicator system for perinasal administration testosterone gel (a) a chamber pre-filled with the plurality of doses of the testosterone gel； (b) an actuator nozzle, said actuator nozzle comprising an outlet channel and a tip and having a shape that conforms to the interior surface within the nasal cavity.WO 2012/156822 PCT/IB2012/001127 1/29 134 130 102 132 100 144 128 150 126 122 120 .124 FIG. 1
