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Nasal gels of controlled release of testosterone, Methods and Systems for Administration pernasal multidose pre Loaded Applicators
专利权人:
TRIMEL PHARMACEUTICALS CORPORATION
发明人:
申请号:
ARP120101721
公开号:
AR089553A1
申请日:
2012.05.16
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
It also relates to methods and Systems for Applicators without air, multiple dose prefilled, pernasal Gel For nasal Administration of testosterone. Claim 1: a testosterone Gel For topical intranasal Administration in a nasal Cavity to control the release of testosterone over a period of at least approximately.6 hours after Administration in the nasal Cavity to provide a replacement of testosterone in a man for the treatment of testosterone deficiency in men, without causing unacceptable in a sudden Peak Blood levels of testosterone in men during the useful Life of The doseThe testosterone gel intranasal comprises: (a) testosterone in an effective amount to treat testosterone deficiency in men; (b) at least one vehicle lyophilic or partially lipophilic; (c) a supersolvente to increase solubility of testosterone in the Gel Test Osterona intranasal; and (d) a viscosity Regulating Agent in an amount effective to controlThe release of this testosterone testosterone gel intranasal Said, where the testosterone gel intranasal doesn't need a surfactant.Claim 5: testosterone gel intranasal according to claim 4, wherein Said oil is selected from a group consisting of Oils, Castor Oil, Almond Oil, Flaxseed Oil, Canola Oil, Coconut Oil, Corn Oil, Cottonseed Oil Cotton, Palm Oil, peanut oil, Poppy Seed Oil,Soybean oil, and mixtures of these.Claim 13: testosterone gel intranasal according to claim 1, wherein Said lipophilic vehicle is selected from a group of lipophilic vehicles consisting of a paraffin, mineral oil, Isopropyl Myristate, Isopropyl Palmitate, capril CAPRYLATE A Methyl stearate, a medium chain triglyceride, Propylene glycol dicaprylate / dicaprate,,A cetostearyl alcohol, stearyl alcohol and mixtures of these. Claim 18: testosterone gel intranasal according to any one of claims 1 to 13, where the supersolvente is selected from a group consisting of Dimethyl isosorbide, Diethylene glycol monoethyl ether, glycerol, Polyethylene glycol, 1 Methyl 2 pyrrolidone and D. Al
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