Compounds having the structure or their salts:are used to treat or reduce the likelihood of acquiring androgen－dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. The compounds can be formulated together with pharmaceutically acceptable diluents or carriers or otherwise made into any pharmaceutical dosage fom. Combinations with other active phamaceutical agents are also disclosed.一種具有下列結構的化合物或其鹽：其可使用來治療或減低獲得雄性激素相依性疾病的可能性，諸如前列腺癌、攝護腺肥大、多囊性卵巢症候群、粉刺、多毛症、皮脂漏、雄性激素禿及雄性禿頭。該化合物可與醫藥上可接受的稀釋劑或載劑一起配製，或其它方面其可製成任何醫藥劑形。本發明亦揭示出與其它活性醫藥試劑的組合。
