Compounds having the structure or their salts:are used to treat or reduce le likelihood of acquiring androgen－dependent diseases, such as prostate cancer, benign prostatichyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. They can be formulated together with pharmaceutically acceptable diluent or carrier or otherwise made into any pharmaceutical dosage form. Some of these compounds having tissue－specific antiandrogenic activity and tissue－specific androgenic activity can be used to treat or reduce the risk of developing diseases related to loss of androgenic stimulation. Combinations with other active pharmaceutical agents are also disclosed.具有下列結構式的化合物或其鹽類：係用於治療雄性激素依存型疾病或降低其罹患可能性，雄性激素依存型疾病諸如前列腺癌、良性前列腺增生過度、多囊性卵巢徵候群、痤瘡、多毛症、皮脂溢、雄性激素性脫毛症及雄性禿。其等可與藥學上可接受的稀釋劑或載劑一起配製，或在其他情況下製成任一種藥學劑型。部份的該等化合物具有組織專一性的抗雄性激素活性與組織專一性的雄性激素活性，可用於治療與雄性激素刺激作用喪失相關的疾病或降低其發生風險。亦揭露與其他活性藥劑之組合物。
