GROMADA JESPER,LATRE S E STHER,MURPHY ANDREW J,YANCOPOULOS GEORGE D,MORTON LORI C
申请号：
IN201637006432
公开号：
IN201637006432A
申请日:
2016.02.24
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention provides antibodies that bind to Activin A and methods of using the same. According to certain embodime nts of the invention the antibodies are fully human antibodies that bind to Activin A with high affinity. The antibodies of the invention are useful for the treatment of diseases and disorders characterized by decreased muscle mass or strength such as sarcopenia cachexia muscle injury muscle wasting/atrophy cancer fibrosis and weight loss. The antibodies of the invention are also useful in combination with GDF8 binding proteins for the treatment of diseases and disorders characterized by decreased muscle mass or strength. The antibodies of the invention are also useful for the prevention treatment or amelioration of disorders and diseases caused by promoted by exacerbated by and/or aggravated by Activin A such as renal fibrosis.
