NOUVEAU DÉRIVÉ DE 1,2,3,4-TÉTRAHYDROQUINOXALINE QUI A, COMME SUBSTITUANT, UN GROUPE PHÉNYLE DANS LEQUEL EST INTRODUITE UNE STRUCTURE D'ESTER D'ACIDE SULFONIQUE OU UNE STRUCTURE D'AMIDE D'ACIDE SULFONIQUE ET QUI POSSÈDE UNE ACTIVITÉ DE LIAISON AUX RÉCEPTEURS DES GLUCOCORTICOÏDES
The compounds represented in general formula (1) or a salt thereof are useful for glucocorticoid receptor modulators. In the formula, R 1 represents a lower alkyl group, a lower cycloalkyl group, an aryl group and the like； R 2 represents a hydrogen atom, a lower alkyl group and the like； R 3 represents a hydrogen atom, a lower alkyl group and the like； R 4 and R 5 represent a hydrogen atom, a lower alkyl group and the like； R 6 represents a hydrogen atom, a lower alkyl group and the like； R 7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group and the like； W represents an oxygen atom, a sulfur atom, NR 8 and the like； R 8 represents a hydrogen atom, a lower alkyl group and the like； X represents an oxygen atom or a sulfur atom； Y represents a lower alkylene group and the like； Z represents an oxygen atom, a sulfur atom, NR 9 , OCO or OSO 2 ； R 9 represents a hydrogen atom, a lower alkyl group and the like respectively.
