Terrance A. STADHEIM,Joana M. MURAD,Jake REDER,Henry C. MARSH, JR.,Li-Zhen HE,Tibor KELER
申请号：
US16477609
公开号：
US20190336534A1
申请日:
2018.01.12
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention provides chimeric antigen receptors (CARs) that specifically bind to the T-cell immunoglobulin and mucin domain 1 (TIM-1) protein. The invention further relates to modified immune cells, e.g., T or NK cells, comprising such CARs, CAR-encoding nucleic acids, CAR-encoding vectors, and methods of making such compositions. The invention further relates to methods for therapeutic use of these CARs and modified immune cells for the treatment of a condition, disorder, or disease associated with cells expressing TIM-1 (e.g., cancer).
