ZHAO YANGBING,REN JIANGTAO,LIU XIAOJUN,JUNE CARL H
申请号：
IN201717014032
公开号：
IN201717014032A
申请日:
2017.04.20
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR a chain TCR chain beta 2 microglobulin a HLA molecule CTLA 4 PD1 and FAS and further comprising a nucleic acid encoding a modified T cell receptor (TCR) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (CAR). Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition such as an autoimmune disease.
