RÉCEPTEURS ANTIGÉNIQUES CHIMÉRIQUES CIBLANT TIM-1

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专利权人:

Celdara Medical, LLC;Celldex Therapeutics, Inc.

发明人:

HE, Li-Zhen,MARSH, Jr., Henry, C.,KELER, Tibor,STADHEIM, Terrance, A.,MURAD, Joana, M.,REDER, Jake

申请号：

EP18739365

公开号：

EP3568416A4

申请日:

2018.01.12

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

The invention provides chimeric antigen receptors (CARs) that specifically bind to the T-cell immunoglobulin and mucin domain 1 (TIM-1) protein. The invention further relates to modified immune cells, e.g., T or NK cells, comprising such CARs, CAR-encoding nucleic acids, CAR-encoding vectors, and methods of making such compositions. The invention further relates to methods for therapeutic use of these CARs and modified immune cells for the treatment of a condition, disorder, or disease associated with cells expressing TIM-1 (e.g., cancer).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/