SRIVATSA SRINIVASAN, SURABHI,NAGARAJAN, NIRANJANA ADITI,PANOWSKI, SILER,PARK, YOON,SAI, TAO,SASU, BARBRA JOHNSON,VAN BLARCOM, THOMAS JOHN,DUSSEAUX, MATHILDE BRUNNHILDE,GALETTO, ROMAN ARIEL
申请号：
CA3089318
公开号：
CA3089318A1
申请日:
2019.01.31
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic methods for use of these CARs and engineered immune cells comprising these CARs for the treatment of a condition associated with malignant cells expressing CD70 (e.g., cancer).
