HERVE GENESTE,MICHAEL OCHSE,KARLA DRESCHER,CLARISSA JAKOB
申请号：
ARP130102932
公开号：
AR092167A1
申请日:
2013.08.16
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Formula compound (1),Acceptable salts on N-oxide, Tao Qiang Ji, by-products and drugs are inhibitors of type 10A phosphates, which are used in drug manufacturing to make them suitable for the treatment or control of diseases selected between neurological disorders and mental disorders, In order to alleviate the symptoms related to these diseases and reduce the risk of this disease. 1. Characteristic requirement 1: a compound whose characteristic is formula (1),In formula (1), variables X, y, R1,R2,R3,R83088 and r83099 have the following meanings: X is c-r8310o or N； and it is c-r8311o or N； R1 is selected from groups of hydrogen, halogen, cyanogen, nitrogen and R1,Oh, Oran,S (o) qr1 cubic,C (O) H C (O) RC (O) OH C (O) OROC (O) RY -NR RY -N (R) -Y -NR RY1-n (r1.8313) - y2-r1.8309；； 74919 and a z1-ar1；2. From the group consisting of R2,Oran,C (o) R2 cubic,C (O) ORY1 - No. 8309； No. 8310；Y -N (R) -Y -NR RY1-n (R 2.8311) - y2-r 2.8312 and one Z 2-ar2,R2 can also be hydrogen, if R1 is different from hydrogen and oh, or R3 is different from hydrogen； R3 should be selected from groups of hydrogen, halogen, cyanogen, nitrogen and R3 1,Oran,S (O) QR3C (O) H C (O) RC (O) OH C (O) OROC (O) RY -NR RY -N (R) -Y -NR R y Y -N (R) -Y -RZ3-AR3；R830808 was selected from the group consisting of hydrogen, halogen, cyanogen, nitrogen and r83081；Or8308；]S (O) qRC (O) H C (O) RC (O) OH C (O) OROC (O) RY -NR RY -N (R) -Y -NR RY -N (R) -Y -Rand Z⁴-Ar⁴；R830909 was selected from the group consisting of hydrogen, halogen, cyanogen, nitrogen and r83091；Or830982.,S (O) qRC (O) H C (O) RC (O) OH C (O) OROC (O) RY -NR RY -N (R) -Y -NR RY -N (R) -Y -Rand Z⁵-Ar⁵；O r830808 and r83099；Together with the carbon atoms connected to them, they can form a c-periodic or aperiodic merging ring composed of 5, 6 or 7 members. In this ring, the fused c-periodic or aperiodic ring may be saturated, partially unsaturated or unsaturated or aromatic. In this ring, there may be one different periodic ring, Two or thre
