A silver-containing tissue dressing for providing antimicrobial properties to a wound site is disclosed. In some embodiments, the tissue dressing may include a wound contact layer having a substrate material coated with a tacky hydrophobic silicone material, and silver-containing particles dispersed in the silicone material. The different surfaces of the substrate material may be coated with the silicone material having various amounts of tackiness. The silver material may provide antimicrobial properties when the tissue dressing is placed in contact with the wound site.
