Alexander Richard Liam Cecil;Franck Alexandre Silva;Thomas James Hill;Stephen Joseph Shuttleworth
发明人:
Stephen Joseph Shuttleworth,Franck Alexandre Silva,Alexander Richard Liam Cecil,Thomas James Hill
申请号：
US13384310
公开号：
US08981087B2
申请日:
2010.07.23
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Compounds of formula (I): wherein: W is O, N—H, N-alkyl, N-alkenyl, N-alkynyl, N-aryl, N-heteroaryl or S； each X is independently CH or N； R1 is formula (b) or R3 is H, alkyl, NH2, OH, =0 or halogen； each A and B are independently CH or N； D is NHR4； R4 is H, alkyl, —C(O)-alkyl. —C(O)—NH2, —C(O)—NH-alkyl, —SO2-alkyl, —SO2—NH2 or —SO2—NH-alkyl； R2 is aryl substituted with at least one nitrogen-containing group or R2 is a nitrogen-containing heteroaryl, cycloalkyl substituted with a nitrogen-containing group, nitrogen-containing cycloalkyl, C1-C6 mono alkylamino, C1C6 bis alkylamino, C1C6 acylamino, C1-C6 aminoalkyl, mono (C1C6 alkyl)amino C1-C6 alkyl, bis (C1C6 alkyl)amino C1C6 alkyl, C1-C6-acylamino or C1 C6 alkynyl-NR11, R11 is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, halogen, O-alkyl, NH-alkyl, N-dialkyl, —C(O)—R7, —C(O)—NH2, —C(O)—NH—R7, —SO2—R7, —SO2—NH2, —SO2—NH—R7, NH-acyl, NH-sulfonyl, NR7-acyl, NR7-sulfonyl, N—C(O)—NH—R7, N—SO2—NH—R7, N—C(O)—NR7R7 or N—SO2—NR7R7； and R7 is alkyl, aryl or heteroaryl, are useful as PI3K inhibitors and are useful in therapy.
