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Macrolide derivative substituted in the 4 position C
专利权人:
TAISHO PHARMACEUTICAL CO. LTD.
发明人:
申请号:
IL22766313
公开号:
IL227663A
申请日:
2013.07.25
申请国别(地区):
IL
年份:
2017
代理人:
摘要:
The compounds of the present are effective against resistant bacteria (e.g. Erythromycin resistant pneumococci, Streptococci and Mycoplasma).Claim 1: a compound represented by the formula (1) wherein in the formula I is a Methyl Group r1 represents a hydrogen Atom, an alkyl group (C1 - 6 - 6 alkyl group C1 can be replaced with one or two hydroxy substituents selected from a Group, a group Coxi C1 - 6, an amino Group, a group alquilamino C1 - 6 and a group represented by the formula nr78cor79,Or the Formula - nr80so2r81, R78 and R80, which may be identical or different, represent a hydrogen Atom, an alkyl group or C1 - 6 and r79 and R81, which may be identical or different, represent an alkyl group C1 - 6), or a Group alquilsulfonilo C1 - 6 R2 represents an Atom HydrogenA saturated Heterocyclic Group of 4 to 8 members (the saturated Heterocyclic Group can be substituted with one or two substituents selected from a Group aralquilo C7 and 12 alkyl group C1 - 6), a group alcanoilo C1 - 6 (the Group alcanoilo C1 - 6 can be substituted with an amino group or a group Alquilamino C1 - 6)Or an alkyl group C1 - 6 can be substituted with 1 to 3 substituents selected from the group of substituents or 1, R1 and R2 can be combined together to form, together with nitrogen Atom to which they BIND.A nitrogen saturated Heterocyclic Group containing 4 to 8 members (the saturated Heterocyclic Group containing nitrogen can be substituted with 1 to 3 substituents selected from a hydroxyl Group, an amino Group, a group alquilamino C1 - 6, and an alkyl group (C1 - 6 alkyl group C1 6 can be substituted with an amino Group.Or a group alquilamino C1 - 6)) The Substituent Group 1 is a group formed by a Group alquilsulfonilo C1 - 6, 6 - alkoxy Group C1, C3 - 6 a cycloalkyl Group, a Hydroxy Group, a phenyl Group (The phenyl Group can be substituted with alkoxy groups C1 1 - 6 3 (d) a saturated Heterocyclic Group And 4 to 8 members (the saturated Heterocyclic Group can be substituted with alkyl g
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